Methionine aminopeptidase 2 inhibition: antiangiogenesis and tumour therapy
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چکیده
منابع مشابه
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.
Methionine aminopeptidase (MetAP) carries out an important cotranslational N-terminal methionine excision of nascent proteins and represents a potential target to develop antibacterial and antitubercular drugs. We cloned one of the two MetAPs in Mycobacterium tuberculosis (MtMetAP1c from the mapB gene) and purified it to homogeneity as an apoenzyme. Its activity required a divalent metal ion, a...
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The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased synovial vascularity, and hence is a potential therapeutic target for angiogenesis inhibitors. We examined t...
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ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Patents
سال: 2004
ISSN: 1354-3776
DOI: 10.1517/eotp.14.1.1.25668